Various Types of HIV Mixed Infections in Cameroon
Identifieur interne : 001238 ( Main/Exploration ); précédent : 001237; suivant : 001239Various Types of HIV Mixed Infections in Cameroon
Auteurs : Jun Takehisa [Japon] ; Léopold Zekeng [Cameroun] ; Eiji Ido [Japon] ; Innocent Mboudjeka [Japon] ; Hiroyuki Moriyama [Japon] ; Tomoyuki Miura [Japon] ; Masahiro Yamashita [Japon] ; Lutz G. Gürtler [Allemagne] ; Masanori Hayami [Japon] ; Lazare Kaptué [Cameroun]Source :
- Virology [ 0042-6822 ] ; 1998.
Descripteurs français
- Wicri :
- geographic : Cameroun.
English descriptors
- KwdEn :
- Academic press, Amino acid residues, Amino acid sequences, Asymptomatic carrier, Cameroon, Cameroonian, Cameroonian specimens, Central africa, Central african country, Clone, Consensus sequence, Different subtypes, Divergent strains, Double infection, Dual infection, First round, Genetic analysis, Greater variety, Group primers, High frequency, Human immunodeficiency virus, Human immunodeficiency virus type, Immune defic, Immunodeficiency, Infection, Inner pair, Mosaic genomes, Multiple sequences, Multiple strains, National institute, Nucleotide, Nucleotide substitutions, Other hand, Other subtypes, Outer pair, Phylogenetic, Phylogenetic analysis, Phylogenetic tree, Phylogenetic trees, Present study, Primer, Probable cases, Rapid communication, Recombinant, Recombination, Same genome, Same subtypes, Subtype, Subtypes, Triple infection, Various subtypes, Various types, Virol.
- Teeft :
- Academic press, Amino acid residues, Amino acid sequences, Asymptomatic carrier, Cameroon, Cameroonian, Cameroonian specimens, Central africa, Central african country, Clone, Consensus sequence, Different subtypes, Divergent strains, Double infection, Dual infection, First round, Genetic analysis, Greater variety, Group primers, High frequency, Human immunodeficiency virus, Human immunodeficiency virus type, Immune defic, Immunodeficiency, Infection, Inner pair, Mosaic genomes, Multiple sequences, Multiple strains, National institute, Nucleotide, Nucleotide substitutions, Other hand, Other subtypes, Outer pair, Phylogenetic, Phylogenetic analysis, Phylogenetic tree, Phylogenetic trees, Present study, Primer, Probable cases, Rapid communication, Recombinant, Recombination, Same genome, Same subtypes, Subtype, Subtypes, Triple infection, Various subtypes, Various types, Virol.
Abstract
In order to assess the incidence of HIV mixed infection as well as to clarify the molecular epidemiology of HIV in central Africa, we investigated 43 HIVs obtained from 211 Cameroonian AC, ARC, and AIDS patients in 1994 and 1995. Part of thepolregion and part of theenvregion were phylogenetically analyzed. The genotypes observed were varied: of 43 specimens, 28 (65%) were subtype A, 1 (2%) was subtype B, 2 (5%) were subtype D, 3 (7%) were subtype F, and 2 (5%) were group O. Of the remaining 7 specimens, 3 were mixed infections with HIV-1 subtypes A and C, HIV-1 subtypes C and F, and HIV-2 subtype A and HIV-1 subtype A; 1 was a mixed infection with HIV-1 subtypes A and D and the highly divergent group O (triple infection); another 3 appeared to consist of mosaic genomes (A/G, A/E, and B/A recombinant). These data show that various types of mixed infection, such as between different subtypes of HIV-1 group M, between HIV-1 and HIV-2, and even between HIV-1 groups O and M, were confirmed at a rather high frequency (approximately 10%). The mixed infection is particularly significant where there is a greater variety of HIV-1 subtypes circulating, since it results in new genetic diversity generated by intersubtype recombination.
Url:
DOI: 10.1006/viro.1998.9141
Affiliations:
- Allemagne, Cameroun, Japon
- Bavière, District de Haute-Bavière, Région du Kansai
- Kyoto, Munich
- Université Louis-et-Maximilien de Munich, Université de Kyoto
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Le document en format XML
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type="ISSN">0042-6822</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Academic press</term><term>Amino acid residues</term><term>Amino acid sequences</term><term>Asymptomatic carrier</term><term>Cameroon</term><term>Cameroonian</term><term>Cameroonian specimens</term><term>Central africa</term><term>Central african country</term><term>Clone</term><term>Consensus sequence</term><term>Different subtypes</term><term>Divergent strains</term><term>Double infection</term><term>Dual infection</term><term>First round</term><term>Genetic analysis</term><term>Greater variety</term><term>Group primers</term><term>High frequency</term><term>Human immunodeficiency virus</term><term>Human immunodeficiency virus type</term><term>Immune defic</term><term>Immunodeficiency</term><term>Infection</term><term>Inner pair</term><term>Mosaic genomes</term><term>Multiple sequences</term><term>Multiple strains</term><term>National institute</term><term>Nucleotide</term><term>Nucleotide substitutions</term><term>Other hand</term><term>Other subtypes</term><term>Outer pair</term><term>Phylogenetic</term><term>Phylogenetic analysis</term><term>Phylogenetic tree</term><term>Phylogenetic trees</term><term>Present study</term><term>Primer</term><term>Probable cases</term><term>Rapid communication</term><term>Recombinant</term><term>Recombination</term><term>Same genome</term><term>Same subtypes</term><term>Subtype</term><term>Subtypes</term><term>Triple infection</term><term>Various subtypes</term><term>Various types</term><term>Virol</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Academic press</term><term>Amino acid residues</term><term>Amino acid sequences</term><term>Asymptomatic carrier</term><term>Cameroon</term><term>Cameroonian</term><term>Cameroonian specimens</term><term>Central africa</term><term>Central african country</term><term>Clone</term><term>Consensus sequence</term><term>Different subtypes</term><term>Divergent strains</term><term>Double infection</term><term>Dual infection</term><term>First round</term><term>Genetic analysis</term><term>Greater variety</term><term>Group primers</term><term>High frequency</term><term>Human immunodeficiency virus</term><term>Human immunodeficiency virus type</term><term>Immune defic</term><term>Immunodeficiency</term><term>Infection</term><term>Inner pair</term><term>Mosaic genomes</term><term>Multiple sequences</term><term>Multiple strains</term><term>National institute</term><term>Nucleotide</term><term>Nucleotide substitutions</term><term>Other hand</term><term>Other subtypes</term><term>Outer pair</term><term>Phylogenetic</term><term>Phylogenetic analysis</term><term>Phylogenetic tree</term><term>Phylogenetic trees</term><term>Present study</term><term>Primer</term><term>Probable cases</term><term>Rapid communication</term><term>Recombinant</term><term>Recombination</term><term>Same genome</term><term>Same subtypes</term><term>Subtype</term><term>Subtypes</term><term>Triple infection</term><term>Various subtypes</term><term>Various types</term><term>Virol</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Cameroun</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In order to assess the incidence of HIV mixed infection as well as to clarify the molecular epidemiology of HIV in central Africa, we investigated 43 HIVs obtained from 211 Cameroonian AC, ARC, and AIDS patients in 1994 and 1995. Part of thepolregion and part of theenvregion were phylogenetically analyzed. The genotypes observed were varied: of 43 specimens, 28 (65%) were subtype A, 1 (2%) was subtype B, 2 (5%) were subtype D, 3 (7%) were subtype F, and 2 (5%) were group O. Of the remaining 7 specimens, 3 were mixed infections with HIV-1 subtypes A and C, HIV-1 subtypes C and F, and HIV-2 subtype A and HIV-1 subtype A; 1 was a mixed infection with HIV-1 subtypes A and D and the highly divergent group O (triple infection); another 3 appeared to consist of mosaic genomes (A/G, A/E, and B/A recombinant). These data show that various types of mixed infection, such as between different subtypes of HIV-1 group M, between HIV-1 and HIV-2, and even between HIV-1 groups O and M, were confirmed at a rather high frequency (approximately 10%). The mixed infection is particularly significant where there is a greater variety of HIV-1 subtypes circulating, since it results in new genetic diversity generated by intersubtype recombination.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Cameroun</li><li>Japon</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li><li>Région du Kansai</li></region><settlement><li>Kyoto</li><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li><li>Université de Kyoto</li></orgName></list><tree><country name="Japon"><region name="Région du Kansai"><name sortKey="Takehisa, Jun" sort="Takehisa, Jun" uniqKey="Takehisa J" first="Jun" last="Takehisa">Jun Takehisa</name></region><name sortKey="Hayami, Masanori" sort="Hayami, Masanori" uniqKey="Hayami M" first="Masanori" last="Hayami">Masanori Hayami</name><name sortKey="Ido, Eiji" sort="Ido, Eiji" uniqKey="Ido E" first="Eiji" last="Ido">Eiji Ido</name><name sortKey="Mboudjeka, Innocent" sort="Mboudjeka, Innocent" uniqKey="Mboudjeka I" first="Innocent" last="Mboudjeka">Innocent Mboudjeka</name><name sortKey="Miura, Tomoyuki" sort="Miura, Tomoyuki" uniqKey="Miura T" first="Tomoyuki" last="Miura">Tomoyuki Miura</name><name sortKey="Moriyama, Hiroyuki" sort="Moriyama, Hiroyuki" uniqKey="Moriyama H" first="Hiroyuki" last="Moriyama">Hiroyuki Moriyama</name><name sortKey="Yamashita, Masahiro" sort="Yamashita, Masahiro" uniqKey="Yamashita M" first="Masahiro" last="Yamashita">Masahiro Yamashita</name></country><country name="Cameroun"><noRegion><name sortKey="Zekeng, Leopold" sort="Zekeng, Leopold" uniqKey="Zekeng L" first="Léopold" last="Zekeng">Léopold Zekeng</name></noRegion><name sortKey="Kaptue, Lazare" sort="Kaptue, Lazare" uniqKey="Kaptue L" first="Lazare" last="Kaptué">Lazare Kaptué</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Gurtler, Lutz G" sort="Gurtler, Lutz G" uniqKey="Gurtler L" first="Lutz G." last="Gürtler">Lutz G. Gürtler</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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